Literaturdatenbank
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Fauth, J. E., Reece, J. S., Downs, C. A., & Ehrhart, L. M. (2004). Cellular diagnostics and health of juvenile green turtles (chelonia mydas): Identifying environmental cofactors of fibropapillomatosis. (draft).
Added by: Admin (06 Jan 2014 18:24:24 UTC) |
| Resource type: Journal Article BibTeX citation key: Fauth2004 View all bibliographic details  |
Categories: General Keywords: Chelonia mydas, Cheloniidae, Schildkröten - turtles + tortoises, Veterinärmedizin - veterinary medicine, Viren - viruses Creators: Downs, Ehrhart, Fauth, Reece Collection: (draft) |
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| URLs http://www.helping ... 31R-Manuscript.pdf |
| Abstract |
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Fibropapillomatosis (FP), a tumor-causing disease caused by a herpes virus, is becoming increasingly common in marine turtles worldwide. In central Florida, FP is common in juvenile green turtles (Chelonia mydas) foraging in heavily-eutrophied Indian River Lagoon (IRL) and increasing in frequency on a near-shore sabellarid worm rock reef (SWRR), but very rare in a Trident submarine basin (TSB). In 2004-2005, blood samples were collected from juvenile C. mydas and turtle health was evaluated in these three sites. Cellular-diagnostic analysis indicated that compared to individuals at the other two sites, IRL turtles had elevated levels of enzymes involved in xenobiotic detoxification pathways, oxidative stress response, and protein metabolic condition. Elevated levels of cytochrome P450 classes 2 and 3 implicate electrophilic drugs and environmental pollutants and steroid-based compounds as likely contaminants. Elevated levels of cytochrome P450-2 class and heat shock protein 70 (which re-natures denatured proteins) were significantly correlated with reduced body condition. Elevated levels of heat shock protein 70 also were significantly correlated with increased probability of FP tumors. An in vitro experiment on mononuclear cells incubated with malathion, endosulfan, or solvent controls confirmed that cellular-diagnostic profiles of IRL were consistent with pesticide stress. These results show that cellular diagnostics can identify likely environmental cofactors associated with a viral disease, thereby providing evidence of a linkage between anthropogenic pollutants and declining health in a federally-endangered sea turtle.
Added by: Admin |