Literaturdatenbank
Literaturdatenbank |
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Ramaglia, V., Harapa, G. M., White, N., & Buck, L. T. (2004). Bacterial infection and tissue-specific hsp72, -73 and -90 expression in western painted turtles. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 138(2), 138–148.
Added by: Admin (14 Aug 2008 20:38:54 UTC) |
| Resource type: Journal Article BibTeX citation key: Ramaglia2004 View all bibliographic details  |
Categories: General Keywords: Bakterien = bacteria, Chrysemys, Chrysemys picta, Emydidae, Schildkröten = turtles + tortoises, Veterinärmedizin = veterinary medicine Creators: Buck, Harapa, Ramaglia, White Collection: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology |
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| Abstract |
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Heat shock proteins (Hsps) are molecular chaperones that assist intracellular folding, assembly and translocation of proteins in prokaryotic and eukaryotic cells. A variety of stresses including hyperthermia, radiation, heavy metals, ischemia, anoxia and reoxygenation have been shown to increase the expression of Hsps. Likewise, bacterial infection represents a stress for the host cell. In this study, expression of the constitutive (Hsp73) and inducible (Hsp72) isoforms of Hsp70 and Hsp90 was monitored in brain, heart, liver and skeletal muscle from the western painted turtle Chrysemys picta bellii diagnosed with Septicemic Cutaneous Ulcerative Dermatitis (SCUD). This disease is caused by a gram-negative Bacterium probably belonging to the Citrobacter spp. The expression of Hsp73 increased 1.8-fold in brain and liver, 2.2-fold in heart but did not change in skeletal muscle; Hsp72 expression increased 5.5-fold in brain and 3-fold in liver but did not change in heart or skeletal muscle; Hsp90 expression increased 9-fold in brain, 2.7-fold in heart and 2.4-fold in skeletal muscle but did not change in liver. These results suggest a tissue-specific Hsp response during bacterial infection and a role for Hsps in immunopathological events in reptiles. 2004 Elsevier Inc. All rights reserved.
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