Literaturdatenbank
Literaturdatenbank |
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Sladky, K. K., Miletic, V., Paul-Murphy, J., Kinney, M. E., Dallwig, R. K., & Johnson, S. M. (2007). Analgesic efficacy and respiratory effects of butorphanol and morphine in turtles. Journal of the American Veterinary Medical Association, 230(9), 1356–1362.
Added by: Admin (14 Aug 2008 20:32:49 UTC) Last edited by: Sarina Wunderlich (17 Oct 2008 16:46:48 UTC) |
| Resource type: Journal Article DOI: 10.2460/javma.230.9.1356 BibTeX citation key: Sladky2007 View all bibliographic details  |
Categories: General Keywords: Emydidae, Schildkröten = turtles + tortoises, Trachemys, Trachemys scripta, Untersuchungsmethoden = examination method, Veterinärmedizin = veterinary medicine Creators: Dallwig, Johnson, Kinney, Miletic, Paul-Murphy, Sladky Collection: Journal of the American Veterinary Medical Association |
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| Abstract |
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Objective-To test the hypothesis that butorphanol or morphine induces antinociception with minimal respiratory depression in conscious red-eared slider turtles. Design-Prospective crossover study. Animals-37 adult male and female red-eared slider turtles (Trachemys scripta). Procedures-Antinociception (n = 27 turtles) and respiratory (10 turtles) experiments were performed. Infrared heat stimuli were applied to the plantar surface of turtle limbs. Thermal withdrawal latencies were measured before and at intervals after SC administration of physiologic saline (0.9% NaCl) solution, butorphanol tartrate (2.8 or 28 mg/kg ), or morphine sulfate (1.5 or 6.5 mg/kg ). Ventilation was assessed in freely swimming turtles before and after SC administration of saline solution, butorphanol (28 mg/kg), or morphine (1.5 mg/kg). Results-For as long as 24 hours after injection of saline solution or either dose of butorphanol, thermal withdrawal latencies among turtles did not differ. Low- and high-dose morphine injections increased latencies significantly by 8 hours. Ventilation was not altered by saline solution administration, was temporarily depressed by 56% to 60% for 1 to 2 hours by butorphanol (28 mg/kg) administration, and was significantly depressed by a maximum of 83 +/- 9% at 3 hours after morphine (1.5 mg/kg) injection. Butorphanol and morphine depressed ventilation by decreasing breathing frequency. Conclusions and Clinical Relevance-Although widely used in reptile species, butorphanol may not provide adequate antinociception for invasive procedures and caused short-term respiratory depression in red-eared slider turtles. In contrast, morphine apparently provided antinociception but caused long-lasting respiratory depression.
Added by: Admin Last edited by: Sarina Wunderlich |