Literaturdatenbank
Literaturdatenbank |
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James, S. B., Calle, P. P., Raphael, B. L., Papich, M., Breheny, J., & Cook, R. A. (2003). Comparison of injectable versus oral enrofloxacin pharmacokinetics in red-eared slider turtles, trachemys scripta elegans. Journal of Herpetological Medicine and Surgery, 13(1), 5–10.
Added by: Admin (14 Aug 2008 20:37:17 UTC) |
| Resource type: Journal Article BibTeX citation key: James2003 View all bibliographic details  |
Categories: General Keywords: Bakterien = bacteria, Emydidae, Schildkröten = turtles + tortoises, Trachemys, Trachemys scripta, Veterinärmedizin = veterinary medicine Creators: Breheny, Calle, Cook, James, Papich, Raphael Collection: Journal of Herpetological Medicine and Surgery |
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| Abstract |
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Three male and three female red-eared slider turtles, Trachemys scripta elegans, were given an intramuscular (IM) injection of enrofloxacin (5 mg/kg body weight). Blood was obtained from a peripheral vein, and plasma concentrations of enrofloxacin and ciprofloxacin were measured at 0, 0.5, 1, 2, 4, 8, 12, 24, 36 and 48 hr post injection. After a period of six weeks, the same animals were given orral doses of enrofloxacin (10 mg/kg body weight). Blood was obtained and plasma concentrations of enrofloxacin and ciprofloxacin were measured at 1, 2, 5, 8, 12, 24, 36, 48, 72hr post oral dosing. The highest mean concentrations of enrofloxacin and ciprofloxacin were 6.28 g/ml 2 hr and 0.42 g/ml 7.4 hr after IM injection and 3.44 g/ml 5 hr and 0.35 g/ml 6 hr after oral administration. The mean apparent elimination half-life of enrofloxacin was 17.6 hr after IM injection and 32.8 hr after oral administration. the half-life for ciprofloxacins was 28.4 hr post IM administration and 59.6 hr post-oral administration. This study demonstrated that therapeutic blood levels of enrofloxacin could be achieved in red-eared sliders when administrated at 5mg/kg IM or 10mg/kg orally.
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