Literaturdatenbank
Literaturdatenbank |
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Willingham, E. (2004). Endocrine-disrupting compounds and mixtures: Unexpected dose-response. Archives of Environmental Contamination and Toxicology, 46(2), 265–269.
Added by: Sarina Wunderlich (06 Jul 2014 16:17:30 UTC) |
| Resource type: Journal Article BibTeX citation key: anon2004.16604 View all bibliographic details  |
Categories: General Keywords: Emydidae, Graptemys geographica, Graptemys pseudogeographica, Schildkröten - turtles + tortoises, Zeitigung - incubation Creators: Willingham Collection: Archives of Environmental Contamination and Toxicology |
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| Abstract |
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The current study examined the effects on the red-eared slider turtle of extremely low doses of three endocrine-disrupting compounds (EDCs)--trans-Nonachlor, chlordane, and p,p'-DDE-singly and in mixtures. Previous studies using the red-eared slider turtle have proven its value as an organism for obtaining information about the effects of endocrine-disrupting compounds. The sex of the turtle, easily manipulated by exposure during embryogenesis, continues to be a marker of effects. When red-eared slider turtle embryos incubating at a temperature that normally produces a male-biased sex ratio are exposed to these compounds singly, the sex ratio of the resulting hatchlings shifts significantly to a female bias. The current work offers further evidence that the red-eared slider turtle provides a way to quantify the effects of mixtures and has the potential as a model for evaluating additivity and synergy. The results provide information about how very low doses (parts per billion) of these compounds behave in mixtures. The dose ranges were 0.125-0.5 ng/egg for trans-Nonachlor and chlordane and 7-28 ng/egg for p,p'-DDE. Results suggest the possibility that two of the compounds may exert effects in mixtures via complementary pathways; when applied singly, the effects of chlordane and p,p'-DDE were inversely related to dose, but in mixtures, which were essentially a greater dose of EDC, the compounds had an increased effect. In all cases, mixtures resulted in 100% females.
Added by: Sarina Wunderlich |